Docosahexaenoic acid: membrane modification and neurotrophic mechanisms
نویسندگان
چکیده
منابع مشابه
Metabolism and functions of docosahexaenoic acid‐containing membrane glycerophospholipids
Omega-3 (ω-3) fatty acids (FAs) such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are known to have important roles in human health and disease. Besides being utilized as fuel, ω-3 FAs have specific functions based on their structural characteristics. These functions include serving as ligands for several receptors, precursors of lipid mediators, and components of membrane glyc...
متن کاملDocosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms.
Alzheimer disease is characterized by accumulation of the β-amyloid peptide (Aβ) generated by β- and γ-secretase processing of the amyloid precursor protein (APP). The intake of the polyunsaturated fatty acid docosahexaenoic acid (DHA) has been associated with decreased amyloid deposition and a reduced risk in Alzheimer disease in several epidemiological trials; however, the exact underlying mo...
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A key feature of Parkinson disease is the aggregation of α-synuclein and its intracellular deposition in fibrillar form. Increasing evidence suggests that the pathogenicity of α-synuclein is correlated with the activity of oligomers formed in the early stages of its aggregation process. Oligomers toxicity seems to be associated with both their ability to bind and affect the integrity of lipid m...
متن کاملCell cycle regulation in retinal progenitors by glia-derived neurotrophic factor and docosahexaenoic acid.
PURPOSE A recent study has shown that glia-derived neurotrophic factor (GDNF) and docosahexaenoic acid (DHA) promote the survival and differentiation of retina photoreceptors. The current study was undertaken to investigate whether these molecules participate in cell cycle regulation in retinal progenitors in vitro. METHODS Developmental changes in the expression of the stem cell marker nesti...
متن کاملDocosahexaenoic Acid (DHA)
Handling & Preparation Instructions This purified fatty acid is liquid at room temperature (oil) and not soluble in water. The product is supplied sterile. It can be solubilized in undiluted serum, ethanol or DMSO. The solubility of Docosahexaenoic acid in ethanol is at least 100 mg/ml. Docosahexaenoic acid has a solubility of 1 mg/ml in a solution of 0.15 M Tris-HCL (pH 8.5). We strongly recom...
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ژورنال
عنوان ژورنال: Oléagineux, Corps gras, Lipides
سال: 2011
ISSN: 1258-8210,1950-697X
DOI: 10.1051/ocl.2011.0409